Nutrition Health Review

March – April 2020

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Veterans Corner: Health and Wellness Reports from Around the United States

Low-glutamate diet linked to brain changes and migraine relief in veterans with Gulf War Illness. A recent study suggests that following a low-glutamate diet could reduce headaches and migraines among veterans with Gulf War Illness. Compared to healthy controls, veterans with Gulf War Illness had greater cortical thickness and were more likely to experience migraines. After following a low-glutamate diet, cortical thickness significantly decreased among veterans. Reports of migraines among veterans dropped from over 50 percent to less than 20 percent after one month of adhering to the low-glutamate diet. Fatigue, pain, and cognitive dysfunction also improved with a low-glutamate diet. Glutamate is an excitatory neurotransmitter involved in pain mediation. It is commonly found in processed foods, and it occurs naturally in some foods, such as tomatoes and mushrooms. Visit https://medicalxpress.com/news/2025-11-glutamate-diet-linked-brain-migraine.html to read more. Rehabilitation outcomes of service members and veterans with mild-to-moderate traumatic brain injury. In this study, researchers assessed the impact of the Intensive Evaluation and Treatment Program (IETP), an inpatient rehabilitation program, on mild-to-moderate traumatic brain injury (TBI) symptoms among service members and veterans. In total, 127 participants were included for analysis. Mean inpatient stay was 41.5 days. Participants had an average of 7.45 deployments and 16.32 concussion events, most of which were reported to be blast-related. Total Neurobehavioral Symptom Inventory (NSI) and PTSD Checklist for DSM-5 (PCL-5) scores significantly improved from baseline to discharge, and remained improved at six-month follow-up. Patient Reported Outcomes Measurement Information System for Pain Interference (PROMIS-PI) results showed that in pain interference was significantly reduced at discharge and six-month follow-up compared to baseline. Mayo-Portland Adaptability Inventory (M2PI) scores significantly improved from baseline to discharge, but these improvements were not maintained at six-month follow-up. These findings indicate that the IETP was effective in improving symptoms of mild-to-moderate TBI among service members and veterans.  Visit https://pmc.ncbi.nlm.nih.gov/articles/PMC12604533/ to read more. LDL cholesterol improved among veterans in program with health coaches, other resources. A recent study found that participation in the Veterans Affairs Lipid Optimization Reimagined Quality Improvement (VALOR-QI) program led to improvements in low-density lipoprotein (LDL) cholesterol levels among veterans with atherosclerotic cardiovascular disease (ASCVD). The VALOR-QI program aimed to address barriers to optimal cholesterol management among participants. This analysis, which included data from 83,232 veterans, found that the number of veterans who achieved LDL cholesterol levels lower than 70mg/dL increased by 32 percent during the program. Among veterans who participated for two years, 33.5 percent met their LDL cholesterol goals. Thirty-six percent of veterans aged 75 years or older achieved LDL cholesterol levels below 70mg/dL. At baseline, 78 percent of veterans had a prescription for cholesterol-lowering medication, which increased to 88 percent during the program, and patient adherence to medication rose from 65 to 77 percent.  Visit https://newsroom.heart.org/news/ldl-cholesterol-improved-among-veterans-in-program-with-health-coaches-other-resources to read more..

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What is Food Intolerance?

Food intolerance occurs when individuals experience nonimmunological, meaning not related to or caused by an immune response, adverse reactions to a given food.1 Although both conditions fall under the umbrella of food hypersensitivity,2 food intolerance is a distinct entity from food allergy. Food allergy is an immunological adverse reaction that occurs when an individual is exposed to a given food.1 Food intolerance elicits a dose-dependent response, meaning that the severity of the adverse reaction is related to the amount of the ingested food; in contrast, for individuals with food allergies, exposure to even a very small amount of the food allergen can trigger a severe reaction.3 There are various types of food intolerance, but they often share common symptoms that affect the gastrointestinal (GI) tract; these symptoms include abdominal pain, nausea, flatulence, bloating, and diarrhea.2–4 Common types of food intolerance include: Lactose intolerance: Lactose intolerance occurs when individuals with lactose malabsorption (inability to absorb lactose) experience symptoms such as abdominal pain, bloating, and diarrhea following the consumption of lactose-containing foods.2,4 Lactose malabsorption is caused by a deficiency in lactase, the enzyme that digests lactose; lactase deficiency can occur gradually as individual ages, or it can be caused by abnormalities in the intestines as a result of conditions such as viral gastroenteritis, inflammatory bowel disease (IBD), chemotherapy, or malnutrition, among others.2–4 Non-celiac gluten/wheat sensitivity (NCGWS): NCGWS occurs when individuals have a sensitivity to gluten or other components of wheat but lack celiac antibodies or allergic markers. Individuals with NCGWS might experience intestinal symptoms, such as bloating, abdominal pain, and diarrhea, and extraintestinal symptoms, such as fatigue, headache, and weight loss.2,4  Histamine intolerance: It is believed that histamine intolerance stems from increased levels of histamine in the blood due to consumption of histamine-rich foods and an inability to properly metabolize histamine.2–4 It is suspected that a lack of diamine oxidase (DAO) activity contributes to histamine intolerance. In addition to GI symptoms, other symptoms include neurological symptoms (eg, headaches, dizziness) and cardiovascular symptoms (eg, lowered blood pressure, palpitations, tachycardia), as well as rarer respiratory (eg, rhinitis, difficulty breathing) and cutaneous (eg, itching, flushing) symptoms.3,4 Fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs): FODMAPs are short-chain carbohydrates that are poorly digested, which results in the production of short-chain fatty acids (SCFAs) and gas that can then cause symptoms such as abdominal pain, diarrhea, and flatulence, especially in susceptible individuals, such as those with irritable bowel syndrome (IBS). FODMAPs are found in fruits, vegetables, diary, cereals, and sweeteners, and examples include lactose, fructose, fructans, mannitol, and sorbitol.2,4 Hereditary fructose intolerance (HFI): HFI is a rare autosomal disorder wherein individuals cannot metabolize fructose correctly, leading to symptoms such as nausea, abdominal pain, and diarrhea following consumption of foods high in fructose, including honey, fruits, and vegetables.2,4 Non-HFI: Non-HFI stems from an impairment in fructose uptake in the small intestine.2,4 Diagnosis varies based on the type of food intolerance. For example, lactose malabsorption can be diagnosed via enzymatic assays, genetic tests, and noninvasive breath tests,2–4 and HFI can be diagnosed with the use of Benedict’s test and a glucose dipstick test,2,4 whereas determining the presence of NCGWS or FODMAP intolerance largely relies on patient self-reports.4 When NCGS is suspected, the Salerno Experts’ Criteria5 can be utilized for diagnosis. Put simply, this process involves establishing baseline symptoms to a gluten-containing diet, adherence to a gluten-free diet to determine if symptoms improve, and, among those who experience symptom improvement with a gluten-free diet, a gluten challenge. While a hydrogen breath test exists for the diagnosis of non-HFI, results can be inconsistent and its clinical utility is thus debated.2,4 Overall, there is a lack of validated tests for food intolerance, making diagnosis challenging.3,4 Treatments differ based on the type of food intolerance and should be personalized to the individual; treatment commonly involves altering one’s diet to avoid or lower intake of foods that cause adverse reactions.2–4 Bottom line Food intolerance encompasses a variety of conditions that often cause symptoms such as abdominal pain, bloating, and diarrhea. Diagnosis can be challenging, and treatment often involves dietary changes. Consult with a doctor if you suspect you have food intolerance. Sources Boyce JA, Assa’ad A, Burks AW, et al. Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-sponsored expert panel report. J Allergy Clin Immunol. 2010;126(6):1105–1118.  Hage G, Sacre Y, Haddad J, et al. Food hypersensitivity: distinguishing allergy from intolerance, main characteristics, and symptoms-a narrative review. Nutrients. 2025;17(8):1359.  Gargano D, Appanna R, Santonicola A, et al. Food allergy and intolerance: a narrative review on nutritional concerns. Nutrients. 2021;13(5):1638.  Zingone F, Bertin L, Maniero D, et al. Myths and facts about food intolerance: a narrative review. Nutrients. 2023;15(23):4969. Catassi C, Elli L, Bonaz B, et al. Diagnosis of non-celiac gluten sensitivity (NCGS): the Salerno Experts’ Criteria. Nutrients. 2015;7(6):4966–4977.  

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Monoclonal Gammopathy of Undetermined Significance: A Brief Overview

Monoclonal gammopathy of undetermined significance (MGUS) is a plasma cell disorder that is often diagnosed incidentally, meaning that it is found when looking for other disorders or during routine medical tests. MGUS is a premalignant, which means having the potential to progress to malignancy (cancer), and asymptomatic condition.1 To be diagnosed with MGUS, you must meet the following three criteria: serum monoclonal protein (M protein) less than 3mg/dL, clonal bone marrow plasma cells less than 10 percent, and absence of end-organ damage (eg, hypercalcemia, renal insufficiency, anemia, bone lesions) due to the plasma cell disorder.2 There are three types of MGUS: non-immunoglobulin M (IgM) MGUS, IgM MGUS, and light-chain MGUS, and their diagnostic criteria (Box 1), and their progression potential differs slightly.1,3 Since the majority of MGUS cases are non-IgM,1 the remainder of this article will focus on this type.  Prevalence About 2 to 3 percent of adults over the age of 50 years and five percent of those over the age of 70 years have MGUS.1 MGUS is more prevalent in Black individuals compared to White individuals and in men compared to women. Furthermore, people with first-degree relatives with MGUS or multiple myeloma have a greater risk of developing MGUS, which suggests that there might be a genetic component to this condition.1,2  Progression Non-IgM MGUS can progress to smoldering multiple myeloma or multiple myeloma or related disorders.1,3 The risk of progression from MGUS to multiple myeloma or a related disorder is one percent per year, which is very low.4 However, different clinical features can lead to an increased risk of progression. Researchers have developed a risk stratification guide for MGUS. Patients with low-risk MGUS have serum M protein less than 1.5g/dL, IgG subtype, and normal free light chain (FLC) ratio (0.26–1.65); a light chain is a small subunit that is attached to a heavy chain as part of an antibody, and a FLC is a light chain that is unattached to a heavy chain and is present in the blood. The presence of abnormalities in these factors, which includes M protein of 1.5g/dL or greater, non-IgG subtype, and FLC ratio less than 0.26 or greater than 1.65, increases the risk of disease progression. Patients with low-risk MGUS have a five-percent absolute risk of progression at 20 years; this risk increases to 21 percent for patients with low-intermediate–risk MGUS (any 1 abnormality is present), 37 percent for those with high-intermediate–risk MGUS (any 2 abnormalities are present), and 58 percent for those with high-risk MGUS (all 3 abnormalities are present).5  Management Upon diagnosis, patients with MGUS should undergo a complete history and physical, various lab tests (complete blood count [CBC], serum calcium, and creatinine), and a urine protein test.2 At 3 to 6 months post-MGUS diagnosis, serum protein electrophoresis should be performed again to rule out multiple myeloma or Waldenström’s macroglobulinemia (a type of lymphoma).2 Patients with low-risk MGUS typically do not need to undergo bone marrow examination since risk of progression is so low. If stable after 3-to-6-month follow-up for serum protein electrophoresis, patients can be followed every 2 to 3 years or if symptoms of a plasma cell malignancy arise. Patients with low-intermediate–risk MGUS or greater should undergo bone marrow examination to rule out plasma cell malignancy; if there is evidence of malignancy, patients should receive further tests to measure lactate dehydrogenase, beta-2 microglobulin, and C-reactive proteins. If the patient is found to have MGUS, they should undergo serum protein electrophoresis and CBC after six months, then annually for life. Patients with MGUS do not receive active treatment unless part of a clinical trial.2 Conclusion MGUS is an asymptomatic precursor condition to multiple myeloma. Although risk of disease progression is low, patients with MGUS, especially those with high-risk characteristics, should be monitored by a healthcare professional. Sources Kaseb H, Annamaraju P, Babiker HM. Monoclonal gammopathy of undetermined significance. Updated 10 Jul 2022. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2025. https://www.ncbi.nlm.nih.gov/books/NBK507880/ Kyle RA, Durie BG, Rajkumar SV, et al. Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management. Leukemia. 2010;24(6):1121–1127.  Rajkumar SV, Kyle RA, Buadi FK. Advances in the diagnosis, classification, risk stratification, and management of monoclonal gammopathy of undetermined significance: implications for recategorizing disease entities in the presence of evolving scientific evidence. Mayo Clin Proc. 2010;85(10):945–948.  Kyle RA, Therneau TM, Rajkumar SV, et al. A long-term study of prognosis in monoclonal gammopathy of undetermined significance. N Engl J Med. 2002;346(8):564–569.  Rajkumar SV, Kyle RA, Therneau TM, et al. Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance. Blood. 2005;106(3):812–817. 

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Social Determinants of Health and Health Equity

By Sarabeth Lowe, MPH Ms. Lowe is a Communication Specialist at the University of Delaware Disaster Research Center. Welcome to the fourth edition of Health Literacy Highlights, a column that explores topics related to finding, understanding, and utilizing health information. This column is meant to empower you with the skills you need to apply what you already know and use it to maintain and protect your overall health and wellbeing. In this installment of Health Literacy Highlights, I focus on the social determinants of health (SDoH) and their impact on public health.  Health is more than just the absence of disease or injury.1–3 It’s also more than just a matter of your genes and choices. There are a myriad of variables that directly affect our wellbeing, beginning with where we live, work, and play. Upstream factors—the fundamental social, cultural, and political structures and systems in place—are the driving forces behind the health inequities we see every day.4 Efforts to improve health in the United States (US) have traditionally looked to the healthcare system to alleviate these disparities, but this approach often misses the forest for the trees. It’s also largely ineffective. Research and history show that this approach is not working.5–7 Despite being widely recognized and documented for many years, disparities in health and healthcare have persisted and, in some cases, widened over time in the US.8–11 Improving health outcomes and achieving health equity require broader approaches that address social, economic, and environmental factors. This has led many practitioners, researchers, and experts to advocate for a strategy that directly addresses the causes—not the symptoms—of these disparities. In other words, they are calling for going back to basics: social determinants of health (SDoH). What Are SDoH? SDoH are the evolving societal systems, their components, and the resources and hazards for health systems that social systems control, distribute, allocate, and withhold that, in turn, cause health consequences.12 SDoH are also described as:13–17 Nonmedical or nonbiological factors that influence health outcomes, risks, quality of life, and longevity; for example, race itself isn’t a SDoH, but racism and its social manifestations, like a ZIP code’s history of school segregation or redlining, are.18 Conditions and environments in which people are born, grow, work, live, and age. Wider forces and systems that shape the conditions of daily life. Upstream social and economic factors that dictate the health and disease of individuals and populations. In short, SDoH are the “causes behind the causes” of health disparities.13 They describe a simple idea: a person’s health is influenced not just by their behavior or actions, but also by social factors. These factors include a variety of personal, social, and environmental conditions and structures, including economic policies, development agendas, social norms, social policies, climate change, and political structures.14 Notably, many SDoH are out of a person’s control.18 The 5 Domains of SDoH SDoH are one of three priority areas—along with health equity and health literacy—for the fifth and current edition of Healthy People, a federal and decadal initiative that sets goals and objectives to improve the health and wellbeing of people in the US.14,15,17 One of Healthy People 2030’s five overarching goals is specifically related to SDoH: “Create social, physical, and economic environments that promote attaining the full potential for health and wellbeing for all.”19–21 The US Department of Health and Human Services had grouped SDoH into five key areas. Economic stability. This domain refers to the connection between a person’s financial status and their health. It encompasses many factors, including income and expenses, social safety net programs (eg, welfare and food stamps), job stability, employment benefits, socioeconomic status, and the general cost of living.17,18,22,23 All of these factors impact a person’s health. Extensive evidence shows that financially disadvantaged individuals have poorer health outcomes than their wealthier counterparts.24–27 For example, higher wealth and income can lead to better health by providing material and employment benefits that promote good health: safe homes and neighborhoods, paid time off work, health insurance, transportation, education, and more. Having a higher socioeconomic status can also reduce the persistent psychosocial stress associated with not having these material resources, which can lead to chronic disease.24,28,29  Education access and quality. This domain refers to a person’s access to and quality of education, and how well it supports their individual learning needs, including those related to how the brain works.18 It encompasses several factors, such as teacher training, geographic location, school facilities (eg, labs, playgrounds, safe classrooms and buildings), curriculum quality and relevance, material resources, educational infrastructure (eg, leadership, policies, and systems), and access to specialized student programs.30,31 Research shows that education and health are intrinsically linked.32 Education is strongly associated with life expectancy, morbidity, and health behaviors.33 It also increases financial security, stable employment, and social success, playing a critical role in lifting people out of poverty and reducing socioeconomic and political inequalities.32,34,35 Healthcare access and quality. This domain refers to a person’s access to and the quality of health-promoting care and resources, and how well it can meet their physical and mental health needs.18 It encompasses several factors, including affordable and easily attainable care, health literacy, health insurance, regularly visiting a primary care doctor, seeing doctors for illness and injuries, receiving mental and behavioral health services, and responding to medical emergencies.36–38 A number of social and economic issues, such as cost and coverage of care, limited access to providers that accept Medicaid, a shrinking healthcare workforce, and fewer medical services and clinicians in rural areas, take a toll on people’s long-term health and contribute to poor wellbeing outcomes.39–44 Neighborhood and built environment. This domain refers to the place someone lives, including its physical, environmental, and societal conditions and its impact on public health and wellbeing.45–47 These factors are related to your ZIP code and the specific community resources that support your health and safety, such as equitable, affordable, and high-quality housing, sidewalks, low rates of crime and violence, schools, workplaces, places of worship, grocery stores, transportation infrastructure, and green spaces.18,48 This SDoH also encompasses climate change.

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The Ins and Outs of Nasal Irrigation

By Sarabeth Lowe, MPH Ms. Lowe is a Communication Specialist at the University of Delaware Disaster Research Center. As the United States (US) inches closer toward the peak of its flu season, which is expected to be especially brutal this year, it’s worth doing an audit of your medicine cabinet.1–3 In addition to cough drops and pain medicine, you might want to consider adding another treatment to your cold and flu regimen: a neti pot. This tea pot–shaped tool shot into the US mainstream nearly 20 years ago when Dr. Mehmet Oz demonstrated its use on the Oprah Winfrey Show, but the practice of nasal irrigation, or rinsing, dates back to Ayurvedic medical traditions of India in the 15th century.4–6 Thousands of years later, this alternative medicine tool has stood the test of time. Here is what you need to know. What is Nasal Irrigation? Nasal irrigation is a process of gently rinsing the nasal cavity with a saline solution (a mix of water and sodium chloride) to treat conditions such as sinus inflammation, congestion, and allergies.5,7–9 This saltwater liquid flows in one nostril and out the other to help clear your sinuses, which are the hollow, air-filled cavities behind the bones in your face that produce and circulate mucus. Normally, your sinuses remain open and uninflamed, which allows you to breathe easily. However, these small, delicate cavities can cause significant discomfort when they are disturbed.  When you inhale, the mucus in your nose traps all kinds of foreign particles from the air, including viruses, fungi, bacteria, and allergens. This can lead to inflammation, congestion, excess mucus, pain, postnasal drip, and swelling around your eyes, cheeks, nose, or forehead.5,8,10 Nasal irrigation helps wash away this blockage, along with any other allergens or environmental contaminants. The liquid itself also plays a role. Because salt water is slightly lower than freshwater on the pH scale, it is slightly more acidic, which creates an environment that is inhospitable for viruses and makes it harder for them to replicate.8,11 Nasal saline also helps restore one of the body’s natural defense systems. There are microscopic, hair-like projections inside your nose called cilia that serve as a natural filtering system, moving viruses and other foreign particles out of your nose.8,12,13 Nasal saline irrigation helps keep this system up and running. What the Research Says A growing body of research supports the effectiveness of nasal irrigation. In 2021, an international team of experts issued a statement on the best ways to manage common sinus issues, including the chronic inflammation of the nasal and sinus passages. They concluded that regular rinsing with saltwater was among the most effective treatments.5,14,15 A 2012 meta-analysis of ten randomized controlled trials found that nasal saline irrigation produced a 27-percent improvement in nasal symptoms and a 62-percent reduction in the use of allergy medications.16 This approach can also help mitigate the length and spread of acute illness. For example, a recent randomized controlled study of more than 11,000 people showed that nasal saline irrigation, initiated at the first sign of symptoms and performed up to six times each day, reduced the duration of symptomatic illness by two days.8,17 Another study showed that saline irrigation performed every four hours over a 16-hour period decreased COVID-19 viral load by 8.9 percent in hospitalized patients. Notably, the viral load in the control group continued to increase during that time.18 Even with all of these benefits, there are other approaches that can more quickly or effectively reduce the symptoms of acute and chronic sinusitis, including topical nasal steroids and corticosteroids (more commonly known as nasal sprays) or surgical interventions.14,17,19–22 However, some of these options are expensive, require a prescription, or require access to specialized care via an otolaryngologist (an ear, nose, and throat doctor).  Additionally, antibiotics aren’t always an option. Even though these drugs are not designed to treat viruses, and it is well established that they do not shorten the duration or reduce the severity of respiratory tract infections, millions of these prescriptions are given each year to treat these illnesses.24 In fact, a study of more than 49,000 of these patient encounters showed that 42 percent of them were unnecessarily prescribed antibiotics.8,25,26 Antibiotics might make patients feel better in the short term, thanks to their off-target, anti-inflammatory properties, but this effect can also be achieved with other over-the-counter anti-inflammatory drugs, like ibuprofen or naproxen, that can be taken in conjunction with nasal saline irrigation.8,27,28 The overprescription of these drugs is also a major contributor to antibiotic resistance, a pressing and growing public health issue.29–31 Instructions and Safety One of the greatest benefits of nasal irrigation is its convenience; you can do it in your own home! You don’t even need a neti pot. Many pharmacies sell ready-to-go kits with all of the tools you need. Here is how to do it safely. 1. Choose your tools. First, choose your rinsing apparatus. If you don’t have a neti pot, you can also use a syringe or spray bottle. Powered irrigation devices are available, but there is limited data comparing the efficacy of different irrigation tools, and there is no specific recommendation on which one to use.32–34 2. Select your solution. Prepare your saltwater solution. The US Centers for Disease Control and Prevention recommends always using distilled or sterile water, which can be purchased at a pharmacy, or tap water that’s been boiled for at least one minute and cooled.35,36 Mix ½ to ¼ teaspoon of noniodized salt with one to two cups of water.5,7,8 Some experts recommend against using table salt because it has too many additives.37 Note that saltier solutions are not more effective.8 3. Lean and tilt. Next, lean over a sink and tilt your head so that your nose is perpendicular to the surface below. One ear should be facing the ceiling and the other the bottom of the sink. Imagine listening for a sound coming from the drain. 4. Rinse and repeat. Place the tip of the irrigation device into the

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Charting the Course for Scientific Discovery:Navigating Scholarly Research

By Sarabeth Lowe, MPH Ms. Lowe is a Communication Specialist at the University of Delaware Disaster Research Center. Welcome to the third edition of Health Literacy Highlights, a column that explores topics related to finding, understanding, and utilizing health information. This column is meant to empower you with the skills you need to apply what you already know and use it to maintain and protect your overall health and wellbeing. In this installment of Health Literacy Highlights, I focus on how to effectively read journal articles and other scholarly research.  Reading a scientific journal article for the first time can feel like going into uncharted territory. These publications’ sometimes pedantic verbiage, unfamiliar diction, and formal jargon can make them difficult to navigate. Even the sheer scale of the literature presents a challenge; there are nearly 50,000 active scientific peer-reviewed journals worldwide, collectively publishing more than three million articles per year.1,2  Don’t let that intimidate you, though. Making informed decisions about your health requires an understanding of medical literature, and peer-reviewed journals are primary vehicles for communicating research.1 In this case, there’s no way to circumvent the science; the only way out is through. Understanding scholarly research, particularly when it comes to reading journal articles, requires a skill set. Like any other kind of craft, it can be honed and strengthened over time. This article is meant to help you begin to navigate these waters. Learning the Ropes Reading a journal article is a completely different process from reading about the study in a newspaper or consumer health publication. The dense text, stilted rhetoric, and series of complex equations can feel overwhelming, to the point where scholarly research may seem like a monolith. However, like any kind of literature, it comes in different flavors and styles. Understanding their differences is a good starting point for selecting the research you’re looking for.  In its broadest terms, there are two types of journal articles in the biomedical sciences: primary and secondary literature. In a nutshell, the former are reports of original research that address a specific question. These articles, which form the core of scientific publications, are written to present findings on new scientific discoveries or describe earlier work to acknowledge it and place new findings in the proper perspective.3–5 There are several types of primary literature, including letters to the editor, conference proceedings, and, of course, different types of research studies.5 Secondary literature, which includes review articles, practice guidelines, and commentaries, is produced based on the analysis and interpretation of original research and primary literature in a specific field.4 Both primary and secondary literature bring their own strengths. The former contains more specific and actionable data, but the latter expands upon original research, connecting the dots between different studies and providing more context and meaning.3–6 Reviews can be especially helpful for understanding the “big picture” of a topic because they summarize multiple primary research articles and give a sense of the consensus, debates, and unanswered questions within a specific field.6 Both types are published in peer-reviewed journals, which means they undergo and pass a strict evaluation process in which journal editors and other expert scholars critically assess the quality and scientific merit of the article and its research.7 Articles published in a peer-reviewed journal, which is considered the gold standard for scientific publishing, are more valued than ones that are not.5,8 Setting Sail Most scientific articles follow a similar core structure, but certain elements may be omitted depending on the type of study.5,9 These are the key components of an original research article: Title Abstract Introduction Materials and Methods Results Discussion Conclusion Luckily, this structure lends itself well to navigating the content. Many people are familiar with these elements, but not the systematic approach involved in understanding how all of these parts connect. This process is not an intuitive one, and the first rule of thumb might surprise you: never start reading an article from the beginning to the end.5,6,10–12  Some experts suggest identifying the conclusions of the study by reading the title and the abstract first.5 If the article does not have the latter, consider reading the conclusions or summary at the end of the article first. While the title of a journal article is meant to be concise and self-explanatory, the abstract delves into the meat of the study and answers fundamental questions, including what the study is about, how the experiment was conducted, and the main findings. Starting with these elements is an apt place to begin because readers can more quickly evaluate the study’s relevance to their area of interest.5,6  Anchors Aweigh: Navigating the Text If readers deem the article worth pursuing, they can dive further into the rest of the research. At this time, they can read on in chronological order. Introduction. Most research doesn’t start from scratch. The purpose of the introduction is to explain the rationale for conducting the study while establishing what is and what is not already known.5 This section usually starts by summarizing existing knowledge and previous research on the topic, such as a specific health intervention or impact, and ends with the authors identifying the gap(s) in the literature that they are trying to address. The aims and objectives are usually mentioned at the end of the introduction. Materials and methods. The devil is in the details. This section provides a clear overview of the authors’ methodology and study design. It describes the technical details of the experiment, including the instruments used, the number of subjects, sampling methods, measured variables, data collection, and other relevant information.5,9,10 Rarely are all details about the experiment included in this section. The authors are expected to describe their procedures in enough detail to demonstrate the study’s legitimacy and enable other researchers to replicate the experiment. This is vital for the entire field of science, which is built on reproducible data.6 Results. In this section, authors summarize the data, often using tables, graphs, or other figures. Ideally, authors do not provide an interpretation of the

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